Sulphasalazine and gastrointestinal transit.

Slows Gastrointestinal Transit in Rats

R.J. KOSLO, J.L. VAUGHT, A. COWAN, D.E. G M E R E K and F. PORRECA, lntrathecal morphine slows gastrointestinal transit in rats, European J. Pharmacol. 119 (1985) 243-246. Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100/~g/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (...

Effects of Artemisia dracunculus essential oil on diarrhea and intestinal transit time in rat gastrointestinal tract

Introduction: Artemisia dracunculus L. belongs to Asteraceae family, and is a medicinal plant widely used in traditional medicine as a remedy for gastrointestinal disturbances. This study was undertaken to evaluate the effects of essential oil of A. dracunculus (EOAD) on the rat alimentary tract. Methods: The EOAD was extracted by Clevenger apparatus using hydrodistillation. LD50 was calcula...

MORPHINE AND APOMORPHINE INHIBIT GASTROINTESTINAL TRANSIT (GIT) THROUGH TWO DIFFERENT MECHANISMS

Morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. Although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (OIT), the exact mechanism has not yet been identified. On this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of tra...

Measurement of gastrointestinal transit using radioactive chromium.

Effect of Epidural Anesthesia with Lidocaine and Bupivacaine on Gastrointestinal Transit Time in Healthy Dogs

Objective- To evaluate the effect of epidural anesthesia with lidocaine and bupivacaine on transit time of barium sulfate contrast medium through gastrointestinal (GI) tracts in healthy dogs. Design- Prospective, randomized experimental study. Animals-Five healthy mixed breed male dogs with 19.2±7.8 months age and 19.9±3.3 kg weight Procedure- The animals received one of the treatments of sa...